Endocrine Abstracts

Osteopathia striata with cranial sclerosis is an X-linked disease caused by mutation in the gene encoding WTX that controls cell signaling affecting bone turn over. While the disease is almost always lethal in males, females exhibit cranial sclerosis, craniofacial dysmorphism and longitudinal sclerotic striations on the long bones. Here is a case of 25 year old female referred to the metabolic and bone clinic for further assessment of chronic back pain and stiffness of the low...

This is a case of forty six year old lady who is known to have resected stage 3 malignant melanoma diagnosed in 2008. She has recently she was started on Ipilimumab, an anti cytotoxic T cell antigen 4(CTLA-4), a monoclonal antibody as part of clinical trial. After two cycles she developed headaches and an MRI scan showed bulky piruitary with an enhacement in keeping with pituitary hypophysisits. She received Dexamethasone 8 mg twice daily with good symptomatic effect. The head...

Introduction: Immune adverse related events are commonly recognized complications of immune check point inhibitors. Here we identify multiple endocrinopathies occurring concurrently in the same patient. In addition to highlighting the common immune adverse effects seen in other cases.Case 1: 33F Refractory Hodgkins Lymphoma tried on several therapies. She was started on Nivolumab (PD-1) with remarkable response. She developed symptoms of Amenorrhea, gala...

Introduction: Immune adverse related events are commonly recognized complications of immune check point inhibitors. Here we identify multiple endocrinopathies occurring concurrently in the same patient. In addition to highlighting the common immune adverse effects seen in other cases.Case 1: 33F Refractory Hodgkins Lymphoma tried on several therapies. She was started on Nivolumab (PD-1) with remarkable response. She developed symptoms of Amenorrhea, gala...

Background: Hyponatraemia is the most commonly observed electrolyte abnormality in hospitalised patients. The many causes of hyponatraemia may be classified either by volume status or aetiology. Thorough history taking, clinical examination and investigation are necessary in order to accurately determine the cause of hyponatremia and so formulate the most appropriate management plan.Methods: Patients with serum sodium <131 mM were identified by daily...